Manganese activates glycosyl-transferase enzymes, a vital step in collagen cross-linking
錳激活糖基轉移酶,這是膠原蛋白交聯的關鍵步驟
adolescent idiopathic scoliosis (AIS)
少年特發性脊椎側彎(AIS)
Previous studies have shown that vitamin D deficiency and insufficiency are
prevalent in adolescents, including AIS patients.
以前的研究表明,包括AIS患者在內的青少年普遍存在維生素D缺乏和不足。
A series of studies conducted in Hong Kong have shown that as many as 30% of
these patients have osteopenia.
在香港進行的一系列研究表明,這些患者多達30%患有骨質減少。
A significant decrease of zinc content in back muscles was observed in patients with scoliosis.
在患有脊椎側彎的患者中觀察到背部肌肉中鋅含量的顯著降低。
An inbred line of chickens that develops severe scoliosis
發育嚴重脊椎側彎的雞近交系
sing the line of birds derived from the cross, the incidence of the lesion,
defined as a spinal curve greater than 20 degrees,
was influenced by deficiencies of copper, manganese or vitamin B-6.
大於20度的脊柱曲線受到銅,錳或維生素B-6缺乏的影響
In the cross, scoliosis was expressed in 40-50% of birds.
Vitamin B-6, manganese or copper deficiency, however, caused an increase
in expression to 60-75% of birds.
脊柱側彎在40-50%的鳥類中表達。然而,維生素B-6,錳或銅缺乏導致表達增加至60-75%的鳥類。
Genetic factors predictive of severe adolescent idiopathic scoliosis (AIS) are
largely unknown. To identify genetic variation associated with severe AIS,
we performed an exome-wide association study of 457 severe AIS cases and 987 controls.
預測嚴重青少年特發性脊柱側凸(AIS)的遺傳因素在很大程度上是未知的。
為了確定與嚴重AIS相關的遺傳變異,我們對457例嚴重AIS病例和987例對照進行了外顯子組關聯研究。
We find a missense SNP in SLC39A8 (p.Ala391Thr, rs13107325) associated with severe AIS (P = 1.60 × 10−7, OR = 2.01, CI = 1.54–2.62).
我們發現與嚴重AIS相關的SLC39A8中的錯義SNP。
This pleiotropic SNP was previously associated with BMI, blood pressure, cholesterol,and blood manganese level.
這種多效性SNP以前與BMI,血壓,膽固醇和血錳水平相關。
Clinically, the minor allele of rs13107325 is associated with greater spinal curvature, decreased height, increased BMI and lower plasma manganese in our AIS cohort.
臨床上,我們的少年特發性脊柱側彎(AIS)隊列中更大的脊柱彎曲,高度降低,BMI升高和血漿錳降低有關。
In comparison with controls, the serum selenium concentration in the group of
scoliotic patients was significantly decreased p < 0.05
(0.74 +/- 0.13 micromol/L and 0.98 +/- 0.12 micromol/L).
與對照組相比,脊椎側彎患者的血清硒濃度顯著降低
The concentration of zinc, copper, selenium, albumin, and ceruloplasmin in blood plasma and the activity of superoxide dismutase and glutathione peroxidase in erythrocytes were determined in a set of patients with idiopathic scoliosis (n=51).
A significant decrease of selenium concentration (0.50 +/- 0.16 micromol/L) was found when compared with a control group (0.69 +/- 0.07 micromol/L) (p<0.01).
在一組患有特發性脊椎側彎的患者中測定血漿中鋅,銅,硒,白蛋白和血漿銅藍蛋白的濃度
以及紅細胞中超氧化物歧化酶和穀胱甘肽過氧化物酶的活性(n = 51)。
與對照組相比,發現硒濃度顯著降低。
小結1:
由以上可知脊椎側彎缺鋅、銅、錳、硒、維它命C、D、B6。
Collagen changes in congenital and idiopathic scoliosis.
膠原蛋白在先天性和特發性脊椎側彎中發生變化。
Collagen abnormalities in adolescent idiopathic scoliosis have been recorded.
記錄了青少年特發性脊椎側彎的膠原異常。